Searchable abstracts of presentations at key conferences in oncology

oa0001p009 | (1) | PacRim7

Targeting stromal remodelling and cancer stem cell plasticity overcomes chemoresistance in metastatic triple negative breast cancer

Cazet Aurelie , Hui Mun , Elsworth Benjamin , Wu Sunny , Roden Daniel , Chan Chia-Ling , O'Toole Sandra , Watkins D Neil , Taylor Renea , Cox Thomas , Samuel Michael , Martin Miguel , Swarbrick Alexander

The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibroblast (CAF) to provide a supportive niche for the acquisition of a chemo-resistant, cancer stem cell (CSC) phenotype via FGF5 expression and production ...